More rigorous research is required to confirm this result.īioimpedance analysis body composition cancer extracellular-to-intracellular fluid volume ratio survival. The E/I ratio can predict survival time in patients with metastatic cancer. Under normal circumstances, wide variations in salt intake lead to parallel changes in renal salt excretion, such that ECF volume is maintained within narrow limits. In the multivariate analysis, poor performance status, leukocytosis, fluid retention, and E/I ratio were independent prognostic factors, and the E/I ratio was the strongest prognostic factor predicting overall survival (hazard ratio = 3.49, 95% confidence interval = 1.75-6.96, P <. Extracellular fluid (ECF) volume is determined by the balance between sodium intake and renal excretion of sodium. The median overall survival time was 1.6 and 12.5 months in the high E/I and low E/I groups, respectively ( P <. Poor performance status, fluid retention, malnutrition, elevation of C-reactive protein levels, and decreases in hemoglobin, albumin, and protein levels were significantly associated with the high E/I group. This fluid overload usually occurs from compromised regulatory mechanisms for sodium and water as seen commonly in heart failure (CHF), kidney failure, and liver failure. The 87 patients were divided into 2 groups according to the median E/I ratio: a high E/I group (E/I ratio ≥1.0, n = 43) and a low E/I group (E/I ratio <1.0, n = 44). Fluid volume excess (FVE), or hypervolemia, refers to an isotonic expansion of the ECF due to an increase in total body sodium content and an increase in total body water. In total, 87 patients were included in the study. Cox proportional hazards models and Kaplan-Meier analysis were used to identify risk factors for mortality. While both conditions can occur simultaneously, the management, including the rate and type of fluids used may differ. Clinical characteristics, including laboratory test results and nutrition status according to the E/I ratio, were analyzed. Alternatively, volume depletion occurs when there is a loss of extracellular fluid volume. Bioimpedance analysis was used to assess body fluid distribution and the E/I ratio. The interstitial fluid and plasma make up about 97 of the ECF, and a small percentage of this is lymph. Interstitial fluid edit Interstitial fluid is essentially comparable to plasma. Patients aged ≥19 years with metastatic solid tumor were eligible. The volume of extracellular fluid in a young adult male of 70 kg, is 20 of body weight about fourteen liters. This study aimed to investigate whether the extracellular-to-intracellular fluid volume (E/I) ratio can predict survival in patients with metastatic cancer.Ĭlinical data were collected from April 2016 to March 2018.
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